Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment
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منابع مشابه
Correction: Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment
[This corrects the article DOI: 10.1371/journal.pone.0165255.].
متن کاملCardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment
Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1) into a regulatory anti-inflamm...
متن کاملCardiosphere-derived cells for heart regeneration.
www.thelancet.com Vol 379 June 30, 2012 2425 2 Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 2008; 319: 91–93. 3 Lemos B, Branco AT, Hartl DL. Epigenetic eff ects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual confl ict. Proc Natl Acad Sci USA 2010; 107: 15826–31. 4 Spach ...
متن کاملHeart to heart: grafting cardiosphere-derived cells augments cardiac self-repair by both myocytes and stem cells
Compared with highly regenerative potentially be exploited by the body itself namely that bone marrow cells likely organisms such as newts and zebrafish (Kikuchi & Poss, 2012), the capacity of mammalian adult heart tissue to undergo self-repair is insufficient to reconstitute the muscle lost in myocardial infarction, hindering functional recovery from heart attacks and from cell loss occurring ...
متن کاملHuman cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.
OBJECTIVES This study sought to compare the regenerative potency of cells derived from healthy and diseased human hearts. BACKGROUND Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerati...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0165255